Title | Orbital and periocular lymphoma. Experience from a UK tertiary referral centre. |
Submitted by | Giorgio Albanese |
Abstract Number | 205 |
19-236 | |
Review Result | rapid fire presentation |
Purpose | To present clinical features, histology and long-term prognosis of all patients with biopsy-proven orbital and periocular lymphoma presenting to a tertiary referral centre in the UK. |
Methods | A retrospective chart review was carried out for all patients who had histological diagnosis of orbital and adnexal lymphoma from 2005 to 2018. All the biopsies were performed at a UK tertiary referral centre. The notes of 56 patients were reviewed. The main outcomes identified were clinical presentation, histology, rate of orbital involvement from primary disease and relative time interval, treatment and prognosis. |
Results | The median age was 66.7 years, and 57.1% of patients were female. Mean follow-up was 5.8 years. The most common presentation included ptosis (12.5%), lid oedema or fullness (12.5%), diplopia (10.7%), and proptosis (5.4%). Orbital involvement was extraconal in 95 % of the cases, and bony erosion was found in only in 3.6%. 17.9% of patients had primary lymphoma elsewhere and the mean interval prior to the orbital presentation was 5 years. In 30% of patients the orbital histotype was different from the primary site. Extranodal Marginal Zone Lymphoma (EMZL) turned out to be the most common (34.1%). The histotype featuring the lowest Local Recurrence Rate (LRR) was EZML (0.41%) as opposite to Diffuse Large B cell Lymphoma (DLBCL) which featured the highest LLR at 7.3%. |
Conclusion | This is one of the largest single-centre series in the UK where histology of orbital and adnexal lymphoma is reported and correlated with LRR. The most common and least aggressive histotype found is EMZL. Change of histotype between primary site and orbital involvement is not a rare event. Biopsy remains key in the diagnostic work-up. |
Additional Authors
Last name | Initials | City / Hospital | Department |
---|---|---|---|
Albanese | G. | University Hospitals of Leicester NHS Trust | Ophthalmology, Oculoplastics and Orbit Service |
Lokovitis | E. | University Hospitals of Leicester NHS Trust | Ophthalmology, Oculoplastics and Orbit Service |
Malick | H. | University Hospitals of Leicester NHS Trust | Ophthalmology, Oculoplastics and Orbit Service |
Sampath | R. | University Hospitals of Leicester NHS Trust | Ophthalmology, Oculoplastics and Orbit Service |