View 2019 Abstracts

TitleOrbital and periocular lymphoma. Experience from a UK tertiary referral centre.
Submitted byGiorgio Albanese
Abstract Number205
Review Resultrapid fire presentation
Purpose

To present clinical features, histology and long-term prognosis of all patients with biopsy-proven orbital and periocular lymphoma presenting to a tertiary referral centre in the UK.

Methods

A retrospective chart review was carried out for all patients who had histological diagnosis of orbital and adnexal lymphoma from 2005 to 2018. All the biopsies were performed at a UK tertiary referral centre. The notes of 56 patients were reviewed. The main outcomes identified were clinical presentation, histology, rate of orbital involvement from primary disease and relative time interval, treatment and prognosis.

Results

The median age was 66.7 years, and 57.1% of patients were female. Mean follow-up was 5.8 years. The most common presentation included ptosis (12.5%), lid oedema or fullness (12.5%), diplopia (10.7%), and proptosis (5.4%). Orbital involvement was extraconal in 95 % of the cases, and bony erosion was found in only in 3.6%. 17.9% of patients had primary lymphoma elsewhere and the mean interval prior to the orbital presentation was 5 years. In 30% of patients the orbital histotype was different from the primary site. Extranodal Marginal Zone Lymphoma (EMZL) turned out to be the most common (34.1%). The histotype featuring the lowest Local Recurrence Rate (LRR) was EZML (0.41%) as opposite to Diffuse Large B cell Lymphoma (DLBCL) which featured the highest LLR at 7.3%.

Conclusion

This is one of the largest single-centre series in the UK where histology of orbital and adnexal lymphoma is reported and correlated with LRR. The most common and least aggressive histotype found is EMZL. Change of histotype between primary site and orbital involvement is not a rare event. Biopsy remains key in the diagnostic work-up.


Additional Authors

Last nameInitialsCity / HospitalDepartment
AlbaneseG.University Hospitals of Leicester NHS TrustOphthalmology, Oculoplastics and Orbit Service
LokovitisE.University Hospitals of Leicester NHS TrustOphthalmology, Oculoplastics and Orbit Service
MalickH.University Hospitals of Leicester NHS TrustOphthalmology, Oculoplastics and Orbit Service
SampathR.University Hospitals of Leicester NHS TrustOphthalmology, Oculoplastics and Orbit Service