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| Title | Ocular cicatricial pemphigoid in a UK tertiary oculoplastics service – The Leicester experience |
| Number | 320 |
| Author | Agni Mokka |
| Principal Unit where research was undertaken | University Hospitals of Leicester |
| Purpose | To describe diagnostic confirmation rates, treatment pathways, and long-term ocular and surgical outcomes of OCP cases managed across a tertiary oculoplastics-cornea service. |
| Methods | Retrospective case series of patients with clinically diagnosed ocular cicatricial pemphigoid/ocular mucous membrane pemphigoid managed at Leicester Royal Infirmary. Demographics, staging of conjunctival cicatrisation, biopsy/direct immunofluorescence (DIF) results, systemic immunosuppression, relapses, complications, and oculoplastic/corneal interventions were extracted with a follow-up of up to 7 years. |
| Results | 21 patients were included (mean age 74 years; range 41–87), 13 of whom (61.9%) had biopsy confirmation. Patients were managed jointly by cornea and oculoplastics services, frequently presenting with lid malposition requiring entropion repair. Most achieved clinical disease control using systemic corticosteroids with mycophenolate mofetil as the principal steroid-sparing agent; escalation beyond MMF was uncommon. Over follow-up, visual acuity, cicatrisation progression, relapse frequency, ocular surface complications, and surgical outcomes are reported. |
| Conclusion | In our tertiary cohort with long follow-up, conjunctival & buccal mucosa biopsy confirmed disease in approximately two-thirds of clinically suspected OCP, consistent with known limitations reported in the literature. A corticosteroid-to-MMF pathway provided durable control for most patients, supporting MMF as an effective steroid-sparing option in real-world practice. Joint cornea–oculoplastics management is critical for timing and outcomes of entropion repair, as well as ocular surface and vision preservation. |
Additional Authors
| First name | Last name | Hospital / Institution |
|---|---|---|
| Anastasia | Gkiala | |
| Mario-Frank | Farrugia | |
| Navpreet | Dhillon | |
| Antonella | Berry-Brincat |
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