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Title Deceptively Benign: Lessons From Nine Years of Staged Excisions
Number 300
Author Sarah O’Beirne
Principal Unit where research was undertaken Sheffield Teaching Hospitals

Purpose The aim of this study was to determine the rate of benign periocular lesions listed for staged excision due to clinical suspicion of malignancy, and to identify which clinical features most often mimicked malignant characteristics.
Methods This retrospective study was conducted at a tertiary oculoplastic centre. We reviewed all staged excisions performed by a single experienced oculoplastic surgeon over 9 years. Demographic data, lesion laterality, and periocular location were recorded. Clinical notes and preoperative images were evaluated to extract features that appeared most suspicious for malignancy.
Results Of 592 lesions excised during the study period, 58 (9.8%) were histologically benign and required only direct closure or simple reconstruction. The cohort included 53% female and 47% male patients with a mean age of 68 years, and 62% of lesions involving the right side. Lesion sites were the lower eyelid (70.7%), upper lid (15.5%), medial canthus (8.6%), lateral canthus (1.7%), brow (1.7%), and nasal bridge (1.7%). Common clinical signs included a lump (81%), lid margin irregularities (37.9%), telangiectasia (36.2%), shiny or pearly surface (36.2%), redness (34.5%), pigmentation (31%), lash loss (19%), and ulceration (19%). Benign pathologies included viral-related lesions (12), sweat gland lesions (11), seborrhoeic keratoses (11), naevi (7), and smaller numbers of inflammatory, cystic, and vascular lesions.
Conclusion Less than 10% of lesions listed for staged excision were benign, supporting high clinical accuracy in distinguishing malignant periocular disease. Features such as telangiectasia, a shiny or pearly surface, and lid margin irregularity were the most deceptive and frequently associated with benign cases.

Additional Authors

First name Last name Hospital / Institution
Camilla Pagnacco
Jennifer HY Tan


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