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| Abstract ID | 17-111 |
| Title | Systemic absorption of mitomycin-C when used in pterygium surgery. |
| Oral, Poster or Video? | Oral Presentation or e-Poster |
| temp | 413 |
| Review result | [518] |
| Purpose |
To determine whether scleral topical application of mitomycin-C (MMC) results in measurable plasma levels of systemic absorption. |
| Methods |
The study comprised 27 patients passed pterygium surgery with MMC. Patients were asked to provide a blood sample 30 minuts after being treated with MMC 0.2 mg/mL (0.02%) for 60 seconds. Human whole-blood samples were evaluated by HPLC-MS-MS method to determine whether MMC was present. |
| Results |
Twenty seven samples were submitted for evaluation. The amount of MMC in the tested items was defined as below 0.25 ppb (ng/mL). |
| Conclusion |
In this study of 27 patients with topical application of MMC for pterygium surgery, there was no measurable evidence of systemic absorption. Although systemic absorption has been found with use in larger quantities, there is the extremely low likelihood of systemic absorption or toxicity of MMC following pterygium surgery. |
